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desvenlafaxine will raise the amount or impact of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Caution/Check. Desvenlafaxine inhibits CYP2D6; with better desvenlafaxine doses (ie, four hundred mg) minimize the CYP2D6 substrate dose by up to 50%; no dosage adjustment required with desvenlafaxine doses seven consecutive days straight